Throwing Transcription for a Loop: The Role of Chromatin Insulators in the 3D Nucleus
Throwing Transcription for a Loop: The Role of Chromatin Insulators in the 3D Nucleus – Air date: Wednesday, December 14, 2011, 3:00:00 PM Timedisplayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: Interactions among regulatory sequences such as enhancers, promoters and insulators give rise to a three-dimensional structure of the genetic material in the eukaryotic nucleus. We have used 5C and HiC to determine the nature of inter- and intra-chromosomal interactions in the Drosophila genome. The results suggest that each chromosome arm is an independent physical unit in terms of its interactions with the rest of the genome. Each chromosome folds into modules with a hierarchical organization. These modules comprise 80% of the genome, they are composed of different types of chromatin, they have a low gene density, and the genes are expressed at low levels, independent of their chromatin composition. Chromosome modules are separated by inter-module regions that comprise 20% of the genome. Inter-module regions have high gene density and comprise different chromatin types, but genes are expressed at higher levels than in chromosome modules. Inter-chromosome modules contain insulator proteins, which, together with RNA polymerase II, mediate interactions with other inter-chromosome modules. Chromosome modules also interact with each other but these interactions are not enriched in any known proteins. We are attempting to deconstruct this 3D structure into specific classes of interactions and determine their role in gene …
State reforms could give options to wayward teens
Filed under: willard drug treatment program
Among the key proposals will be financial incentives for counties to create community-based treatment programs for nonviolent juvenile offenders as alternatives to incarceration. Lawmakers also … Those reforms, for example, allowed the lowest-risk …
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Burglar held without bond on suspected probation violations
Filed under: willard drug treatment program
Jason R. Wolford, 27, of 1223 Ramona Drive, Willard, was arrested on a Huron County Common Pleas Court probation violation warrant late Monday night. The arrest happened in Clarksfield Township. Huron County Prosecutor … While Wolford is in the Huron …
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